Publications from the Eickholt Laboratory...

Selected Publications

Kreis P, Hendricusdottir R, Kay L, Papageorgiou IE, van Diepen M, Mack T, Ryves J, Harwood A, Leslie NR, Kann O, Parsons M, Eickholt BJ. (2013).
Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN.
PLoS One2013 5;8(8). PMID: 23940795

Berglund FM, Weerasinghe NR, Davidson L, Lim JC, Eickholt BJ, Leslie NR. (2013).
Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110α/PIK3CA but not by HER2 or mutant AKT1.
Oncogene12;32(37):4417-26. PMID: 23085752

Kay, L., Humphreys, L., Eickholt, B.J. and Burrone, J. (2011).
Neuronal activity drives matching of pre- and post-synaptic function during synapse maturation.
Nat Neurosci 14, 688-90. PMID: 21532580

Hernandez-Miranda, L., Cariboni, A., Faux, C., Ruhrberg, C., Cho, J., Cloutier, J. F., Eickholt, B. J., Parnavelas J. G., and Andrews, W., (2011).
Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain.
J Neurosc, 20, 31(16):6174-6187. PMID: 21508241

van Diepen, M. T., Parsons, M., Downes, C. P., Leslie, N. R., Hindges, R. and Eickholt, B. J. (2009).
MyosinV controls PTEN function and neuronal cell size.
Nat Cell Biol 11, 1191-6.
PMID: 19767745

Schwarz, Q., Vieira, J. M., Howard, B., Eickholt, B. J. and Ruhrberg, C. (2008).
Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells.
135, 1605-13. PMID: 18356247

Cosker, K. E., Shadan, S., van Diepen, M., Morgan, C., Li, M., Allen-Baume, V., Hobbs, C., Doherty, P., Cockcroft, S. and Eickholt, B. J. (2008).
Regulation of PI3K signalling by the phosphatidylinositol transfer protein PITPalpha during axonal extension in hippocampal neurons.
J Cell Sci 121, 796-803. PMID: 18285448

Eickholt, B. J., Ahmed, A. I., Davies, M., Papakonstanti, E. A., Pearce, W., Starkey, M. L., Bilancio, A., Need, A. C., Smith, A. J., Hall, S. M. et al. (2007).
Control of Axonal Growth and Regeneration of Sensory Neurons by the p110delta PI 3-Kinase.
2, e869. PMID: 17846664

Chadborn, N. H., Ahmed, A. I., Holt, M. R., Prinjha, R., Dunn, G. A., Jones, G. E. and Eickholt, B. J. (2006).
PTEN couples Sema3A signalling to growth cone collapse.
J Cell Sci
119, 951-957. PMID:16495486

Cole, A. R., Causeret, F., Yaeirgi, G., Hastie, C. J., McLauchlan, H., McManus, E. J., Hernandez, F., Eickholt, B. J., Nikolic, M. and Sutherland, C. (2006).
Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo.
J Biol Chem. PMID: 16611631

Osborne, N. J., Begbie, J., Chilton, J. K., Schmidt, H. and Eickholt, B. J. (2005).
Semaphorin/neuropilin signaling influences the positioning of migratory neural crest cells within the hindbrain region of the chick.
Dev Dyn
232, 939-49. PMID: 15729704

Eickholt, B. J.*, Towers, G. J.*, Ryves, W. J., Eikel, D., Adley, K., Ylinen, L. M., Chadborn, N. H., Harwood, A. J., Nau, H. and Williams, R. S. (2005).
Effects of valproic acid derivatives on inositol trisphosphate depletion, teratogenicity, glycogen synthase kinase-3beta inhibition, and viral replication: a screening approach for new bipolar disorder drugs derived from the valproic acid core structure.
Mol Pharmacol 67, 1426-33. PMID: 15687223

Bron, R., Eickholt, B. J., Vermeren, M., Fragale, N. and Cohen, J. (2004).
Functional knockdown of neuropilin-1 in the developing chick nervous system by siRNA hairpins phenocopies genetic ablation in the mouse.
Dev Dyn
230, 299-308. PMID: 15162508

Brown, M., Jacobs, T., Eickholt, B., Ferrari, G., Teo, M., Monfries, C., Qi, R. Z., Leung, T., Lim, L. and Hall, C. (2004). Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse.
J Neurosci 24, 8994-9004. PMID: 15483118

Eickholt, B. J., Walsh, F. S. and Doherty, P. (2002).
An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling.
J Cell Biol 157, 211-7. PMID: 11956225

Eickholt, B. J., Mackenzie, S. L., Graham, A., Walsh, F. S. and Doherty, P. (1999).
Evidence for collapsin-1 functioning in the control of neural crest migration in both trunk and hindbrain regions. Development 126, 2181-9. PMID: 10207143

Vastrik, I.*, Eickholt, B. J.*, Walsh, F. S., Ridley, A. and Doherty, P. (1999).
Sema3A-induced growth-cone collapse is mediated by Rac1 amino acids 17-32.
Curr Biol 9, 991-8. PMID: 10508610



Kreis P, Leondaritis G, Lieberam I, Eickholt BJ. (2014).
Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders.
Front Mol Neurosci. 1;7:23. PMID: 24744697

Waite K, Eickholt BJ (2010).
The neurodevelopmental implications of PI3K signaling.
Curr Top Microbiol Immunol 346: 245-265. PMID: 20582530

Jackson  R. E. and  Eickholt, B. J. (2009).
Semaphorin Signalling.
Current Biology. PMID: 19602408

Eickholt, B. J. (2008).
Functional diversity and mechanisms of action of the semaphorins.

Development 135, 2689-94. PMID:  18660466

van Diepen, M. T. and Eickholt, B. J. (2008).
Function of PTEN during the formation and maintenance of neuronal circuits in the brain.

Dev Neurosci
30, 59-64. PMID: 18075255

Ahmed, A. and Eickholt, B. J. (2008).
Intracellular kinases in semaphorin signaling.
Adv Exp Med Biol 600, 24-37. PMID: 17607944

Cosker, K. E. and Eickholt, B. J. (2007).
Phosphoinositide 3-kinase signalling events controlling axonal morphogenesis.
Biochem Soc Trans 35, 207-10. PMID: 17371239

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